Javier Bardem & Penelope Cruz: These two met on the sexy 2008 film Vicky Cristina Barcelona and continued their romance off-screen.
One insider tells Us that the high-profile pair, who got together in December 2013, decided that their romance was over following their most recent jaunt to the Cannes Film Festival in the south of France.
Ben Affleck & Jennifer Garner: The famous pair first met on the 2003 set of , and began dating instantly.
They married two years later and have three children together.
The source tells Us that Theron, 39, was the one to break things off with the fellow Oscar winner.
PHOTOS: Charlize and Sean's romance Theron and Penn, 54, had known each other for decades before their friendship blossomed into romance.
MORE: Gwyneth Paltrow Treats Her 11-Year-Old Daughter Apple to 0 Facials Though Charlize has never been married, she dated Irish actor Stuart Townsend for nine years from 2001 until 2010.